Ivacaftor is a pivotal pharmaceutical API and analytical reference standard in the treatment of cystic fibrosis, functioning as a CFTR potentiator that increases the open probability of the CFTR channel at the cell surface. As a quinolinone-based amide, Ivacaftor binds to the CFTR protein and enhances chloride ion transport in epithelial cells, thereby improving mucociliary clearance and reducing the pulmonary complications associated with cystic fibrosis. Ivacaftor has a molecular weight of 392.49 g/mol and appears as a white to off-white powder. Studies in both G551D- and F508del-CFTR expressing cells have shown that Ivacaftor combined with forskolin significantly increases CFTR-mediated chloride secretion. Ivacaftor is supplied with detailed characterization data compliant with regulatory guidelines and serves as both the API for commercial Kalydeco® production and a reference standard for analytical method development and quality control applications.
Product Parameters
|
Parameter |
Specification |
|
Product Name |
Ivacaftor |
|
CAS Number |
|
|
Molecular Formula |
C₂₄H₂₈N₂O₃ |
|
Molecular Weight |
392.49 g/mol |
|
Appearance |
White to light brown powder |
|
Melting Point |
212–215 °C |
|
Boiling Point |
550.4 ± 50.0 °C (Predicted) |
|
Density |
1.187 |
|
Storage Condition |
Refrigerator |
Mechanism Of A ction
Bioactivity
Adverse effects
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