Products

Eluxadoline (CAS 864821-90-9) is a synthetic, orally active mixed opioid receptor modulator featuring a complex peptidomimetic structure. The molecule is designed with a unique pharmacological profile that combines μ-opioid receptor agonist activity with δ-opioid receptor antagonism, while exhibiting minimal κ-opioid receptor affinity.

Eletriptan (CAS 143322-58-1) is a second-generation, orally administered, lipophilic serotonin 5-HT₁B/1D receptor agonist belonging to the triptan class of anti-migraine agents. Chemically, Eletriptan is (R)-3-((1-methyl-2-pyrrolidinyl)methyl)-5-(2-(phenylsulfonyl)ethyl)-1H-indole, featuring an indole core structure with a (R)-configured N-methylpyrrolidine substituent at the 3-position and a phenylsulfonylethyl group at the 5-position.

Abiraterone Acetate (CAS 154229-18-2) is a synthetic androstane steroid derivative and the 3β-acetate ester of abiraterone, formally created by the condensation of the 3β-hydroxy group of abiraterone with acetic acid. This esterification enhances the drug's oral bioavailability compared to its active form, abiraterone.

Abiraterone (CAS 154229-19-3) is a 3β-sterol that is androsta-5,16-dien-3β-ol substituted at position 17 by a 3-pyridyl group. Chemically, Abiraterone is 17-(pyridin-3-yl)androsta-5,16-dien-3β-ol (as per USP). As a steroidal compound, Abiraterone is a potent, irreversible, and selective inhibitor of 17α-hydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues that regulates androgen biosynthesis.

Macitentan (CAS 441798-33-0) is a new, orally active, non-peptide dual ETA and ETB endothelin receptor antagonist. Chemically, Macitentan is N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide, featuring a pyrimidine core with bromophenyl, bromopyrimidinyloxyethoxy, and propylsulfamide substituents.

Ivacaftor (CAS 873054-44-5) is an aromatic amide obtained by formal condensation of the carboxy group of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid with the amino group of 5-amino-2,4-di-tert-butylphenol. Chemically, Ivacaftor is N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide, featuring a quinolinone core linked via an amide bond to a di-tert-butyl-substituted phenol.