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Fmoc-Gln(Trt)-OH (Nα-Fmoc-Nδ-trityl-L-glutamine, CAS 132327-80-1) is a doubly protected L-glutamine derivative featuring the Fmoc (9-fluorenylmethyloxycarbonyl) protecting group at the Nα-amino group and the trityl (Trt, triphenylmethyl) protecting group at the Nδ-side chain amide. This unique dual-protection strategy effectively addresses the inherent challenges of glutamine incorporation in peptide synthesis.

Fmoc-7-Me-Trp-OH (N-Fmoc-7-methyl-L-tryptophan, CAS 1808268-53-2) is an Fmoc-protected non-proteinogenic amino acid derivative featuring a 7-methyl substitution on the indole ring of L-tryptophan. The molecular structure consists of the fluorenylmethyloxycarbonyl (Fmoc) protecting group attached to the α-amino group via a carbamate linkage, with a 7-methyl-L-tryptophan core bearing a carboxylic acid at the C-terminus.

Fmoc-Glu(OtBu)-OH·H₂O (Fmoc-L-glutamic acid γ-tert-butyl ester monohydrate, CAS 204251-24-1) is an Fmoc-protected derivative of L-glutamic acid in which the side-chain γ-carboxyl group is protected as a tert-butyl ester. The molecule features the Fmoc (9-fluorenylmethyloxycarbonyl) group at the N-terminus for temporary protection during SPPS, a free α-carboxylic acid for peptide chain elongation, and a tert-butyl (OtBu) ester protecting the side-chain carboxylate.

Fmoc-L-Pen(Acm)-OH (Fmoc-S-acetamidomethyl-L-penicillamine, CAS 201531-76-2) is an Fmoc-protected derivative of the non-natural amino acid L-penicillamine (β,β-dimethylcysteine). The molecule features a penicillamine core with a tert-butyl (gem-dimethyl) substitution at the β-carbon, a free carboxylic acid, and an N-terminal Fmoc (9-fluorenylmethyloxycarbonyl) protecting group. The thiol group of penicillamine is protected by an acetamidomethyl (Acm) group, which serves as a thiol-protecting moiety that is stable under standard Fmoc SPPS conditions and can be selectively removed using mercuric acetate or iodine to reveal the free thiol for disulfide bond formation.

Fmoc-ThpGly-OH (Fmoc-4-amino-tetrahydropyran-4-carboxylic acid, CAS 285996-72-7) is a specialized Fmoc-protected non-natural amino acid featuring a tetrahydropyran ring fused to the alpha-carbon center. The molecule consists of a rigid six-membered tetrahydropyran (oxane) ring with an amino group at the 4-position, which is protected by the Fmoc (9-fluorenylmethyloxycarbonyl) group, and a carboxylic acid functionality at the same carbon.

Fmoc-Met(O2)-OH (N-α-Fmoc-L-methionine sulfone, CAS 163437-14-7) is an Fmoc-protected derivative of L-methionine in which the sulfur atom has been fully oxidized to the sulfone oxidation state (R-SO₂-R). This structural modification fundamentally alters the electronic and steric properties of the methionine side chain: the sulfone group introduces two oxygen atoms that significantly increase the polarity of the residue while eliminating the redox-sensitive thioether functionality present in native methionine.