Products

Anamorelin (CAS 249921-19-5) is a non-peptidic, orally active ghrelin mimetic and growth hormone secretagogue that functions as a highly selective agonist of the growth hormone secretagogue receptor (GHS-R1a). Structurally, Anamorelin is a complex spiroindole-piperidine compound featuring a central piperidine ring with a benzyl substituent at the 3-position, a trimethylhydrazide carboxamide functionality, and an indole-containing amino acid side chain.

Vilazodone Hydrochloride (CAS 163521-12-8) is the hydrochloride salt form of vilazodone, a small‑molecule antidepressant approved by the U.S. Food and Drug Administration for the treatment of major depressive disorder (MDD) in adults.

Tipiracil Hydrochloride (also known as TPI) is the hydrochloride salt form of tipiracil, a potent and selective inhibitor of thymidine phosphorylase (TPase, EC 2.4.2.4). Chemically designated as 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]pyrimidine-2,4(1H,3H)-dione hydrochloride, Tipiracil Hydrochloride features a pyrimidine ring fused with an imidazole and a pyrrolidine ring system.

Osimertinib Mesylate (AZD-9291 mesylate) is the mesylate salt form of osimertinib, a third-generation, orally bioavailable, irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI). Chemically designated as N-(2-{[2-(dimethylamino)ethyl]methylamino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide methanesulfonate, Osimertinib Mesylate features a quinazoline core with an acrylamide warhead that forms a covalent bond with the C797 residue in the ATP-binding pocket of the EGFR kinase domain, enabling prolonged target inhibition.

A-11 (CAS 2996998-09-3), also known as Lipid A-11 or CICL1, is an ionizable cationic lipid that serves as a building block for the synthesis of lipid‑like nanoparticles (LNPs) for nucleic acid delivery. The molecular structure of A-11 features a complex polyether‑polyamine backbone with multiple ester linkages and terminal alkoxy chains (C55H100N2O14), providing the amphiphilic character necessary for self‑assembly into lipid nanoparticles.

Lipid 88 is an advanced ionizable cationic lipid featuring a highly branched, multi‑arm structure designed for next‑generation mRNA delivery applications. The compound has the molecular formula C₇₉H₁₄₇N₃O₂₀, corresponding to a molecular weight of approximately 1459 g/mol. Structurally, Lipid 88 is built around a central core with multiple branching points, incorporating three tertiary amide‑linked headgroups and a network of polyethylene glycol (PEG)‑like ether linkages. The hydrophobic domain comprises multiple branched, saturated alkyl chains derived from 2‑hexyldecanoic acid. This complex architecture — featuring three protonatable amines, 20 oxygen atoms (primarily as ester and ether linkages), and an extremely high number of rotatable bonds (84) — gives Lipid 88 a highly flexible, three‑dimensional structure that facilitates efficient mRNA encapsulation and endosomal escape. The multiplicity of ionizable amines provides a broadened pH range of ionization, potentially enhancing endosomal escape efficiency across a wider range of endosomal pH values encountered in different cell types.