Products

Abiraterone Acetate (CAS 154229-18-2) is a synthetic androstane steroid derivative and the 3β-acetate ester of abiraterone, formally created by the condensation of the 3β-hydroxy group of abiraterone with acetic acid. This esterification enhances the drug's oral bioavailability compared to its active form, abiraterone.

Abiraterone (CAS 154229-19-3) is a 3β-sterol that is androsta-5,16-dien-3β-ol substituted at position 17 by a 3-pyridyl group. Chemically, Abiraterone is 17-(pyridin-3-yl)androsta-5,16-dien-3β-ol (as per USP). As a steroidal compound, Abiraterone is a potent, irreversible, and selective inhibitor of 17α-hydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues that regulates androgen biosynthesis.

Macitentan (CAS 441798-33-0) is a new, orally active, non-peptide dual ETA and ETB endothelin receptor antagonist. Chemically, Macitentan is N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide, featuring a pyrimidine core with bromophenyl, bromopyrimidinyloxyethoxy, and propylsulfamide substituents.

Ivacaftor (CAS 873054-44-5) is an aromatic amide obtained by formal condensation of the carboxy group of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid with the amino group of 5-amino-2,4-di-tert-butylphenol. Chemically, Ivacaftor is N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide, featuring a quinolinone core linked via an amide bond to a di-tert-butyl-substituted phenol.

Ceritinib (CAS 1032900-25-6) is a highly potent, orally bioavailable, ATP-competitive second-generation tyrosine kinase inhibitor that selectively targets anaplastic lymphoma kinase (ALK). Chemically, Ceritinib is a member of the class of aminopyrimidines—specifically, 2,6-diamino-5-chloropyrimidine in which the amino groups at positions 2 and 6 are respectively carrying 2-methoxy-4-(piperidin-4-yl)-5-methylphenyl and 2-(isopropylsulfonyl)phenyl substituents.

Selexipag (CAS 475086-01-2) is a potent, highly selective, and orally available non-prostanoid agonist of the prostacyclin (PGI₂) receptor (IP receptor). Chemically, Selexipag is a pyrazine derivative with the systematic name 2-(4-((5,6-diphenylpyrazin-2-yl)(isopropyl)amino)butoxy)-N-(methylsulfonyl)acetamide.