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Cabozantinib is a potent, orally active multi-tyrosine kinase inhibitor (TKI) that targets multiple receptor tyrosine kinases involved in tumor growth, angiogenesis, and metastasis. Structurally, Cabozantinib features a quinoline core substituted with a dimethoxyphenyl ether at the 4-position, linked through an amide bond to a fluorophenylcarbamoyl cyclopropane moiety.

Velpatasvir is a potent, second-generation hepatitis C virus (HCV) NS5A inhibitor that has revolutionized the treatment of chronic hepatitis C infection. Structurally, Velpatasvir is a complex synthetic molecule featuring a central biphenyl core linked to two pyrrolidine-based carbamate moieties, with each arm containing a phenyl-substituted imidazole ring system.

Remdesivir is a nucleotide analogue prodrug with broad-spectrum antiviral activity against RNA viruses. Structurally, Remdesivir features a C-nucleoside core based on a 1'-cyano-substituted adenosine analogue, linked to a monophosphoramidate prodrug moiety at the 5'-position.

Denifanstat is a potent, orally bioavailable small-molecule inhibitor of fatty acid synthase (FASN), an enzyme responsible for the de novo synthesis of palmitic acid. Structurally, Denifanstat features a piperidine ring linked to a substituted phenyl group and a pyrazole-containing heterocyclic system, creating a conformationally defined scaffold optimized for FASN active-site binding.

Fexofenadine is a second-generation antihistamine belonging to the class of selective peripheral H₁ receptor antagonists. Structurally, Fexofenadine is the active carboxylic acid metabolite of terfenadine, featuring a diphenylmethyl piperidine core connected via a hydroxybutyl linker to a dimethylphenylacetic acid moiety.

Sacubitril (CAS 149709-62-6), also known as AHU‑377, is a potent neprilysin (NEP) inhibitor and a key component of the angiotensin receptor neprilysin inhibitor (ARNI) class of drugs, used in combination with valsartan for the treatment of heart failure. The molecule features a biphenyl framework with a chiral 2R‑methyl‑4S‑carboxyl propylene amide moiety, with a molecular formula of C₂₄H₂₉NO₅ and a molecular weight of 411.49 g/mol. .